Table 2.
Univariable analysis for disease specific survival.
| Variable | HR | p | CI |
|---|---|---|---|
| Age | 1.06 | <0.001 | 1.04–1.08 |
| Gender | 0.72 | 0.067 | 0.51–1.02 |
| Ethnicity | |||
| Caucasian | 1 | ||
| Black | 1.11 | 0.882 | 0.27–4.55 |
| Other | 1.01 | 0.992 | 0.25–4.12 |
| WHO PS | |||
| 0 | 1 | ||
| 1 | 1.72 | 0.014 | 1.11–2.67 |
| 2 | 4.03 | <0.001 | 2.27–7.14 |
| Grade | |||
| 1 | 1 | ||
| 2 | 1.83 | 0.003 | 1.23–2.74 |
| Ki-67 index | |||
| G1 | 1 | ||
| G2 | |||
| <5 | 1.00 | 0.994 | 0.46–2.16 |
| <10 | 1.28 | 0.429 | 0.69–2.36 |
| ≥10 | 4.0 | <0.001 | 2.16–7.40 |
| Primary | |||
| SI | 1 | ||
| Unknown primary | 1.34 | <0.001 | 1.23–1.46 |
| Distant metastases | 2.23 | 0.001 | 1.39–3.68 |
| Liver metastases | 2.51 | <0.001 | 1.70–3.70 |
| CS | 1.72 | 0.011 | 1.13–2.60 |
| CHD | 2.27 | 0.002 | 1.34–3.83 |
| CgA > 6x ULN | 4.28 | <0.001 | 2.83–6.49 |
| Serotonin > ULN | 1.07 | 0.814 | 0.59–1.94 |
| Liver tests > ULN | 4.94 | <0.001 | 2.92–8.36 |
WHO PS: World Health Organisation Performance Score; G1: grade 1; G2: grade 2; SI: small intestine; UP: unknown primary; CS: carcinoid syndrome; CHD: carcinoid heart disease; CgA: elevated chromogranin A; liver tests: any elevation of alkaline phosphatase; gammaglutyltransferase or bilirubin. ULN: upper limit of normal.