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. 2020 Jul 31;11(8):872. doi: 10.3390/genes11080872

Table 1.

5-HT2c RNA editing status in the brains of patients with MDD and in suicide victims.

Disease Brain Area Single Site Analysis Edited Isoform Reference
MDD FC not altered (sites A, C, D) nd [40]
Suicide victims (SCZ and MDD) FC ↑ A, = C, ↑ D (trend) nd [40]
MDD FC = A, ↑ D (trend) nd [41]
Suicide victims (MDD) FC = A, = B,↑ E, ↓ D, ↑ C (trend) ↑ VGI, ↓ VNI [42]
MDD Cortex ↓ E, ↓ D, ↓ C (all trend) not altered [43]
Suicide victims (MDD) PFC nd ↑VSV [45]
Suicide victims (MDD) ACC nd ↑VNI ↓INV↑ VDV [46]
Suicide victims (MDD) FC nd ↑ VNI [46]

MDD: Major Depressive Disorder; SCZ: schizophrenia; FC: frontal cortex; PFC: prefrontal cortex; ACC: anterior cingulate cortex; nd: not determined.