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. 2020 Aug 1;12(8):2140. doi: 10.3390/cancers12082140

Figure 1.

Figure 1

Cisplatin (CDDP) is natriuretic. Summary graph showing cumulative Na+ excretion in mice that received an Na+ load and treatment with cisplatin (CDDP, the black circles, where n = 5 independent trials with three mice per trial), benzamil (BZM, the white squares, where n = 5 independent trials with three mice per trial) or the vehicle (VEH, the white circles, where n = 5 independent trials with three mice per trial) over a 4 h period. Treatment with BZM significantly increased Na+ excretion at both the 2 h and 4 h time points. Treatment with CDDP significantly increased excretion at the 4 h time point, where BZM and CDDP were not different. * p < 0.05 vs. VEH group.