Table 1.
Clinicopathological features of the BRAFV600-positive papillary thyroid carcinomas.
| Clinical Features | cfBRAFV600E in Plasma (24 Cases) | Wild-Type cfBRAF in Plasma (33 Cases) | p-Value |
|---|---|---|---|
| Age at the time of diagnosis (years) | 45.7 ± 16.9 | 46.5 ± 16.4 | 0.92 |
| Sex (male/female) | 8/16 | 9/24 | 0.62 |
| Tumor subtype | |||
| Classical | 16 (67%) | 22 (67%) | 0.87 |
| Follicular variant | 2 (8%) | 4 (12%) | |
| Tall cell variant | 6 (25%) | 7 (21%) | |
| Tumor size (cm) | 2.99 ± 1.9 | 1.99 ± 1.6 | 0.03 |
| Multifocal growth | 10 (42%) | 24 (73%) | 0.03 |
| Gross extrathyroidal extension | 9 (38%) | 4 (12%) | 0.02 |
| Lymph node metastasis | 16 (67%) | 15 (45%) | 0.27 |
| Distant metastases | 8 (33%) | 4 (12%) | 0.05 |
| Pulmonary micrometastases | 7 (29%) | 3 (9%) | 0.04 |