Box and whisker plots were generated in GraphPad Prism 8 under the Tukey method where the median is indicated by the horizontal bar and outliers indicated.‘·’ = The Outlier mark; more than 3/2 times of the upper quartile. The number of patients with blood results for serum C-reactive protein (CRP) (A), erythrocyte sedimentation rate (ESR) (B), hemoglobin (Hb) (C) and white cell count (WCC) (G) at pre-treatment, 1, 6 and 12 months during treatment were 16, 15, 13 and 11 respectively. The number of patients with blood results for serum alkaline phosphatase (ALP) (D) and alanine transaminase (ALT) (F) at pre-treatment, 1, 6 and 12 months during treatment were 15, 14, 12 and 10 respectively. The number of patients with blood results for serum aspartate transaminase (AST) (E) at pre-treatment, 1, 6 and 12 months during treatment were 14, 13, 11 and 9 respectively. The standard serum reference ranges for paediatric patients are indicated in grey (CRP: 0–5 mg/L, ESR: 1–15 mm/h, Hb: 120–160 g/L, ALP: 100–450 U/L, AST: 10–40 U/L, ALT: 5–30 U/L, WCC: 4.5–13.5 × 109/L).