Table 1.
Echocardiographic parameters tested by day 3 (D3) and day 7 (D7) after procedure. End diastolic Interventricular septum thickness (IVSD); end diastolic left ventricle internal diameter (LVIDD); end diastolic left ventricular posterior wall thickness (LVPWD); end systolic interventricular septum thickness (IVSS); end systolic left ventricular internal diameter (LVIDS); end systolic left ventricular posterior wall thickness (LVPWS); left ventricle ejection fraction (LVEF); fractional shortening (FS); heart rate (HR); cardiac output (CO). * EF: p < 0.001ApTOLL vs. Placebo. FS: p < 0.003 ApTOLL vs. Placebo.
| PARAMETER | PLACEBO D3 | APTOLL D3 | PLACEBO D7 | APTOLL D7 | PARAMETER |
|---|---|---|---|---|---|
| IVSD (mm) | 11.68 ± 0.806 | 10.857 ± 0.61 | 10.124 ± 1.357 | 11.353 ± 1.276 | IVSD (mm) |
| LVIDD (mm) | 37.96 ± 4.219 | 39.511 ± 4.319 | 38.488 ± 8.667 | 38.067 ± 6.052 | LVIDD (mm) |
| LVPWD (mm) | 13.430 ± 2.394 | 9.954 ± 1.746 | 10.475 ± 0.67 | 11.093 ± 2.796 | LVPWD (mm) |
| IVSS (mm) | 15.77 ± 2.264 | 13.562 ± 0.932 | 13.153 ± 2.806 | 14.177 ± 1.678 | IVSS (mm) |
| LVIDS (mm) | 26.28 ± 4.36 | 29.126 ± 3.493 | 27.316 ± 5.860 | 24.705 ± 4.129 | LVIDS (mm) |
| LVPWS (mm) | 15.77 ± 3.383 | 11.024 ± 1.339 | 10.926 ± 1.704 | 11.90 ± 1.722 | LVPWS |
| EF (%) | 49.07 ± 5.91 | 46.31 ± 2.60 | 55.14 ± 4.947 | 66.85 ± 3.196 * | EF (%) |
| FS (%) | 21.25 ± 3.77 | 20.272 ± 1.443 | 28.55 ± 2.530 | 34.75 ± 2.492 * | FS (%) |
| HR (bpm) | 99 ± 31.494 | 111.1O1 ± 27.31 | 103.444 ± 31.269 | 91.875 ± 11.849 | HR (bpm) |
| CO (mL/sec) | 3614 ± 2068.651 | 3940.33 ± 1217.115 | 3801.111 ± 1.826 | 3918.875 ± 1356 | CO (mL/sec) |