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. Author manuscript; available in PMC: 2020 Sep 2.

Published in final edited form as: Cryobiology. 2018 Apr 3;82:106–111. doi: 10.1016/j.cryobiol.2018.03.012

Table 3.

Post-CA serum cytokine levels at different time points

Cytokine (pg/ml)	Baseline (pg/ml)	Time point	Group
Cytokine (pg/ml)	Baseline (pg/ml)	Time point	Sham+V	Sham+PFD	CA+V	CA+PFD

IL-6	7.33±2.09	D1	18.33±2.66	25.15±6.01	51.25±5.09	59.38±15.85
		D3	10.41±3.9	9.62±1.99	14.9±0.6	24.9±8.55
		D7	2.71±1.08	3.04±0.03	298.67±92.63^*,#	16.28±4.76
		D14	7.93±4.22	4.91±4.13	121.33±8.62^*,#	7.78±3.84

IL-10	9.56±1.04	D1	9.4±1.74	5.74±0.52	6.74±0.94	8.53±2
		D3	6.62±1.2	8.82±1.98	8.13±2.18	9.19±1.72
		D7	8.46±1.63	6.82±0.33	9.96±1.43	9.06±1.07
		D14	6.7±2.13	11.24±1.85	12.04±3.75	9.5±1.23

TGFβ1	11020.86±6982.82	D1	15013.69±8676.46	10879.05±4768.49	11746.09±4059.83	6976.26±1503.01
		D3	8141.17±2988.41	5694.94±602.08	9741.66±2867.82	5823.13±481.15
		D7	6807.76±1109.73	7095.07±1355.21	7822.44±2453.08	10447.42±3252.91
		D14	4048.39±242.97	4344.87±1012.34	13196.18±14347.3	8497.5±10993.84

Note: D=day, V=vehicle, PFD=pirfenidone, CA=cryoablation

^*

p<0.001 compared to Sham + Vehicle group

^#

p<0.001 compared to CA + PFD group