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. 2020 Aug 6;12(8):2197. doi: 10.3390/cancers12082197

Figure 3.

Figure 3

The dichotomous role of GPx3 in cancer is illustrated by the divergent associations between GPx3 expression and patient survival. (A) Low-grade glioma and lung adenocarcinomas are two examples where low GPx3 predicts worse overall patient survival. (B) Conversely, high GPx3 predicts worse overall patient survival in stomach and lung squamous cell carcinomas. (C) In cancers where low GPx3 expression is associated with poor outcome, such as lung adenocarcinoma, GPx3 mRNA expression (RNA-sequencing by expectation maximization [RSEM] values) correlates negatively with methylation of the GPX3 gene (Illumina HumanMethylation450 Bead Chip; Pearson’s r = −0.3693, p < 0.0001). Conversely, in lung squamous cell carcinomas there is no association between GPx3 expression (expressed as Reads per Kilobase Transcript values from RNAseq) and GPX3 methylation (Illumina Infinium Human Methylation 27 array). Patient overall survival data, mRNA GPx3 expression and GPX3 methylation data were obtained from the Cancer Genome Atlas (TCGA) using cBioportal.org [120,121]. Kaplan–Meier curves were generated using GraphPad Prism software and curves statistically compared using the log rank test (Mantel–Cox).