Table 4.

Table summarising studies of fisetin in cancer.

Reference	Model	Drug	Cancer Type	Effect
Li et al., 2018 [110]	In vitro and in vivo mouse xenograft	Fisetin alone	Triple negative breast cancer	Inhibition of proliferation, migration and metastases
Xiao et al., 2018 [111]	In vitro and in vivo mouse xenograft	Fisetin and fisetin micelles	Ovarian cancer	Antiproliferative and proapoptotic effects
Jia et al., 2019 [112]	In vitro and in vivo mouse xenograft	Fisetin alone	Pancreatic cancer	Antiproliferative
Youns et al., 2017 [113]	In vitro	Fisetin alone	Hepatic, colorectal, and pancreatic	Growth arrest and apoptosis
Yan et al., 2018 [114]	In vitro	Fisetin alone	Gastric cancer	Antiproliferative and pro-apoptotic
Yang et al., 2012 [115]	In vitro	Fisetin alone	Breast cancer	Induction of apoptosis
Lin et al., 2015 [116]	In vitro and in vivo	Fisetin and sorafenib	Cervical cancer	Combination superior to either agent alone in anticancer efficacy
Pal et al., 2015 [117]	In vivo mouse model	Fisetin and sorafenib	BRAF mutated melanoma cells	Reduced proliferation, increased apoptosis and reduced metastases in combination
Khan et al., 2019 [118]	In vivo mouse model	Fisetin and 5FU	Colorectal cancer	Reduced incidence of colorectal cancer formation with Fisetin alone and in combination
Zhuo et al., 2015 [119]	In vitro	Fisetin and cisplatin	Lung adenocarcinoma	Increased apoptosis and decreased viability with combination
Touil et al., 2011 [120]	In vivo mouse model	Fisetin and cyclophosphamide	Lung cancer	92% growth inhibition of combination compared to single agent
Farsad-Naemi et al., 2018 [121]	Randomised clinical trial of dietary supplement dose of Fisetin	Oxaliplatin and capecitabine chemotherapy ± Fisetin 100 mg daily for 7 weeks	Colorectal cancer	Reduced levels of inflammatory mediators (IL8, CRP and MMP7) in Fisetin group. Tumour response was not reported