Table 1.
Patient tumor-related and surgical characteristics.
| Variables | Patients N = 50 (%) |
|---|---|
| Median age at first surgery (years, range) | 52.6 (31.9–75.1) |
| FIGO stage at primary diagnosis | |
| I | 2 (4%) |
| II | 3 (6%) |
| III A | 2 (4%) |
| III B | 3 (6%) |
| III C. | 31 (62%) |
| IV | 4 (8%) |
| Not available | 5 (10%) |
| Histology | |
| Serous | 45 (90%) |
| Endometrioid | 2 (4%) |
| Clear cell | 2 (4%) |
| Not available | 1 (2%) |
| Grading | |
| G1 | 1 (2%) |
| G2 | 4 (8%) |
| G3 | 40 (80%) |
| Not available | 5 (10%) |
| BRCA status | |
| BRCA 1 mut | 5 (10%) |
| BRCA 2 mut | 2 (4%) |
| VUS | 3 (6%) |
| Negative | 5 (10%) |
| Unknown | 35 (70%) |
| Type of surgery at diagnosis | |
| Upfront | 37 (74%) |
| IDS | 11 (22%) |
| No surgery (exploratory laparotomy) | 2 (4%) |
| Postoperative tumor residual at first surgery | |
| CC-0 | 16 (32%) |
| CC > 0 | 25 (50%) |
| Unknown | 9 (18%) |
| Median PFS at primary recurrence (months, range) | 7.5 (0–33) |
| Primary platinum-resistant | |
| Yes | 20 (40%) |
| No | 30 (60%) |
| Treatment at first recurrence | |
| Not surgery | 32 (64%) |
| Surgery | 18 (36%) |
| CT before surgery for platinum resistance | |
| Yes | 32 (64%) |
| No | 18 (36%) |
|
Median PFI from last platinum regimen (months, range) (information available for 31 cases, missing in 19) |
3.0 (0–5.0) |
|
Median number of previous CT lines before surgery for platinum resistance (N, range) (information available for 49 cases, missing in 1) |
3 (1–7) |
| Median number of previous surgeries before surgery for platinum resistance (N, range) | 1 (1–4) |
Legend: N = number; FIGO = International Federation of Gynecology and Obstetrics; BRCA = breast cancer; VUS = variant of unknown significance; IDS = interval debulking surgery; LPT = laparotomy; CC = completeness of cytoreduction; PFS = progression-free survival; CT = chemotherapy; PFI = platinum-free interval at first recurrence.