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. 2020 Jul 29;13(8):171. doi: 10.3390/ph13080171

Table 1.

ESI-MS detected species formed by NPM1264–277 and compound 2 at 24 h of incubation. The experimental m/z values and their charge, the experimental and theoretical molecular weight, and the corresponding species are reported. TFA: trifluoroacetate.

m/z Signal Charge Experimental MW Theoretical MW Species
886.47
1771.93		 A + 2
A + 1		 1770.93 ± 0.01 1770.91 Monomer (NPM1264–277(M))
708.83
885.97
1181.63
1771.93		 B + 5
B + 4
B + 3
B + 2		 3541.19 ± 0.95 3539.82 Dimer (NPM1264–277(D))
746.78
1118.72		 C + 3
C + 2		 2236.37 ± 0.94 2234.27 NPM1264–277(M) + 1 compound 2 – 2 HCl + 1 TFA
736.65
1104.48		 D + 3
D + 2		 2207.28 ± 0.48 2206.26 NPM1264–277(M) + 1 compound 2 – 2 HCl – 1 CO + 1 TFA
1002.23
1335.97
2004.43		 E + 4
E + 3
E + 2		 4005.54 ± 0.93 4003.16 NPM1264–277(D) + 1 compound 2 – 2 HCl + 1 TFA
796.18
994.48
1326.63
1988.96		 F + 5
F + 4
F + 3
F + 2		 3975.64 ± 1.08 3975.15 NPM1264–277(D) + 1 compound 2 – 2 HCl – 1 CO + 1 TFA
1118.47
1491.32		 G + 4
G + 3		 4470.40 ± 0.53 4466.55 NPM1264–277(D) + 2 compound 2 – 4 HCl + 2 TFA
1111.71
1481.64		 H + 4
H + 3		 4442.35 ± 0.46 4438.49 NPM1264–277(D) + 2 compound 2 – 4 HCl – 1 CO + 2 TFA
1104.23
1471.97		 I + 4
I + 3		 4412.90 ± 0.01 4410.48 NPM1264–277(D) + 2 compound 2 – 4 HCl – 2 CO + 2 TFA