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. 2020 Aug 2;10(8):511. doi: 10.3390/brainsci10080511

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Evolution of the heartrate (HR) over time. The two timelines show the mean HR for the four chronologically ordered baseline (BL_1,2,3,4) and stimulation (ST_1,2,3,4) periods of 3 min each independent of rhyme and voice familiarity. Note that infants familiar (EG) and unfamiliar (CG) with prenatal stimulation show distinct HR. Especially in the second part the EG seems to show habituation and deceleration of the HR as revealed by paired-sample t-tests. Data is pooled from the same babies recorded twice at week two and week five of age. BL_end refers to the last 3 min baseline following four baseline and stimulation periods. * = statistical significance p < 0.05; Error bars = ±1 SEM.