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. 2020 Aug 13;10(8):1178. doi: 10.3390/biom10081178

Figure 1.

Figure 1

(A) Alanyl-glutamine (AlaGln) dose-dependently increased transendothelial resistance (TER) in human umbilical vein endothelial cells (HUVEC) incubated with cell medium (ANOVA p < 0.001). (B) gives representative zonula occludens-1 (ZO-1) and claudin-5 (CLDN5) stainings of HUVEC treated with increasing doses of AlaGln Scale bar = 50 µm, (C) the mean and SD values of the fluorescence signal quantification of both endothelial junction proteins. Endothelial ZO-1 abundance is decreased and CLDN5 increased with 8 mM AlaGln. A.U.= arbitrary units. * p < 0.05, ** p < 0.01, *** p < 0.001.