Table 1.
Patient demographics.
| Control | Stage II PAD | Stage IV PAD | |
|---|---|---|---|
| Number of Subjects | 14 | 15 | 16 |
| Mean Age (years) | 67.3 ± 1.3 | 64.3 ± 1.2 | 69.4 ± 1.0 |
| Ankle Brachial Index | 1.09 ± 0.03 | 0.60 ± 0.03 ** | 0.18 ± 0.06 **,ǂ |
| Gender (male/female) | 14/0 | 15/0 | 15/1 |
| Smoking (never/current/former) | 6/6/2 | 0/6/9 | 2/9/5 |
| Coronary artery disease | 4/14 | 3/15 | 8/16 |
| Cerebrovascular disease (none/TIA A/stroke) | 13/1/0 | 13/0/2 | 12/1/3 |
| Obesity B | 6 | 3 | 4 |
| Dyslipidemia | 10 | 8 | 7 |
| Diabetes Mellitus | 2 | 2 | 8 *,† |
| Chronic Obstructive Pulmonary Disease | 0 | 3 | 1 |
| Renal insufficiency C | 1 | 0 | 7 *,ǂ |
| Statins | 9 | 12 | 9 |
| Family history of cardiovascular disease | 5 | 7 | 14 *,† |
| Hypertension | 8 | 9 | 14 |
Continuous variables are presented as mean ± standard error of the mean and were analyzed with the Kruskal-Wallis test. Categorical variables were analyzed with the Yates’ Continuity Corrected Chi-square test. Significantly different from control at p < 0.05 * or p < 0.005 **. Significantly different from Stage II PAD at p < 0.05 † or p < 0.005 ǂ. A Transient Ischemic Attack. B Body Mass Index > 30 kg/m2. C Creatinine Clearance < 60 mL/min/1.73 m2.