Table 2.
Correlation between HSP70 Expression and Clinicopathological Characteristics in HCC Patients.
| Characteristic | Group | HSP70 High Expression | HSP70 Low Expression | p Value |
|---|---|---|---|---|
| Gender | Male | 9 | 7 | 0.4013 |
| Female | 7 | 2 | ||
| Age (years) | <50 | 3 | 0 | 0.5343 |
| ≥50 | 15 | 7 | ||
| AFP (ng/mL) | <400 | 12 | 5 | >0.9999 |
| ≥400 | 6 | 2 | ||
| Etiology | Hepatitis B | 2 | 0 | 0.7124 |
| Hepatitis C | 4 | 3 | ||
| Alcohol | 5 | 1 | ||
| NASH | 1 | 1 | ||
| Autoimmune | 1 | 0 | ||
| Vinyl chloride | 0 | 1 | ||
| Colorectal metastasis | 0 | 1 | ||
| Unknown | 5 | 0 | ||
| Liver cirrhosis | Present | 9 | 3 | >0.9999 |
| Absent | 9 | 4 | ||
| Tumor size (cm) | <5 | 11 | 6 | 0.3623 |
| ≥5 | 7 | 1 | ||
| Tumor number | Single | 15 | 4 | 0.2985 |
| Multiple | 3 | 3 | ||
| Edmondson-Steiner grade | G1 | 0 | 1 | 0.0439 * |
| G2 | 9 | 5 | ||
| G3 | 9 | 1 | ||
| ECGO PS | 0 | 16 | 7 | >0.9999 |
| 1 | 2 | 0 | ||
| Child-Pugh class | A | 17 | 7 | >0.9999 |
| B | 1 | 0 | ||
| BCLC stage | 0 + A | 16 | 4 | 0.1130 |
| B | 2 | 3 | ||
| TNM stage | I + II | 10 | 6 | >0.9999 |
| III | 6 | 3 | ||
| Recurrence | Positive | 10 | 2 | 0.3783 |
| Negative | 8 | 5 | ||
| Recurrence Pattern | Intrahepatic only | 8 | 1 | 0.5665 |
| N = 12 | Extrahepatic only | 1 | 0 | |
| Both | 2 | 0 | ||
| Ki-67 expression | High | 7 | 4 | 0.6564 |
| Low | 11 | 3 | ||
| Midkine expression | High | 10 | 5 | 0.6592 |
| Low | 8 | 2 | ||
| Patient survival (%) | 1-year OS | 82.35 | 83.33 | 0.7055 |
| 1-year PFS | 47.06 | 62.5 | 0.1031 | |
| 3-year OS | 49.91 | 83.33 | 0.5712 | |
| 3-year PFS | 37.65 | 62.5 | 0.5290 | |
| 5-year OS | 49.91 | 0 | 0.5528 | |
| 5-year PFS | 37.65 | 0 | 0.3706 |
Abbreviations: *, p < 0.05; PFS, progression-free survival.