Table 4.
Association between Clinicopathological Characteristics and Prognosis in HCC Patients.
| Characteristic | OS | PFS | ||
|---|---|---|---|---|
| No. of Patients (Died/Total) | p Value (Log-Rank-Test) | No. of Patients (Progress/Total) | p Value (Log-Rank-Test) | |
| Gender | ||||
| Male | 5/16 | 0.6030 | 7/16 | 0.9294 |
| Female | 4/9 | 6/9 | ||
| Age (years) | ||||
| <50 | 1/3 | 0.4527 | 1/3 | 0.2139 |
| ≥50 | 8/22 | 12/22 | ||
| AFP (ng/mL) | ||||
| <400 | 5/17 | 0.1863 | 7/17 | 0.0368 * |
| ≥400 | 4/8 | 6/8 | ||
| Etiology | ||||
| Hepatitis B | 0/2 | 0.2367 | 0/2 | 0.3502 |
| Hepatitis C | 2/7 | 3/7 | ||
| Alcohol | 2/6 | 3/6 | ||
| NASH | 1/2 | 1/2 | ||
| Autoimmune | 0/1 | 0/1 | ||
| Vinyl chloride | 0/1 | 1/1 | ||
| Colorectal metastasis | 0/1 | 0/1 | ||
| Unknown | 4/5 | 5/5 | ||
| Liver cirrhosis | ||||
| Present | 4/12 | 0.6010 | 5/12 | 0.2579 |
| Absent | 5/13 | 8/13 | ||
| Tumor size (cm) | ||||
| <5 | 5/17 | 0.4959 | 6/17 | 0.0239 * |
| ≥5 | 4/8 | 7/8 | ||
| Tumor number | ||||
| Single | 6/19 | 0.0744 | 9/19 | 0.1204 |
| Multiple | 3/6 | 4/6 | ||
| Edmondson-Steiner grade | ||||
| G1 | 0/1 | 0.5090 | 0/1 | 0.9778 |
| G2 | 4/14 | 7/14 | ||
| G3 | 5/10 | 6/10 | ||
| ECGO PS | ||||
| 0 | 8/23 | 0.7663 | 12/23 | 0.4295 |
| 1 | 1/2 | 1/2 | ||
| Child-Pugh class | ||||
| A | 9/24 | 0.4214 | 13/24 | 0.3483 |
| B | 0/1 | 0/1 | ||
| BCLC stage | ||||
| 0 + A | 8/20 | 0.4364 | 10/20 | 0.6930 |
| B | 1/5 | 3/5 | ||
| TNM stage | ||||
| I + II | 4/16 | 0.4385 | 5/16 | 0.0415 * |
| III | 5/9 | 8/9 | ||
| Recurrence | ||||
| Positive | 5/12 | 0.7374 | 9/12 | 0.3079 |
| Negative | 4/13 | 4/13 | ||
| Recurrence Pattern | ||||
| Intrahepatic only | 4/9 | 0.6937 | 6/9 | 0.3380 |
| Extrahepatic only | 1/1 | 1/1 | ||
| Both | 0/2 | 2/2 | ||
| Ki-67 expression | ||||
| High | 3/11 | 0.2863 | 5/11 | 0.6943 |
| Low | 6/14 | 8/14 | ||
| Midkine expression | ||||
| High | 4/15 | 0.5037 | 6/15 | 0.4995 |
| Low | 5/10 | 7/10 | ||
Abbreviations: *, p < 0.05.