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. 2020 Jul 28;12(8):2082. doi: 10.3390/cancers12082082

Figure 1.

Figure 1

Influence of X-linked genes on skin cutaneous melanoma (SKCM) patient survival. (a) Forrest plot of hazard ratios for median survival according to high or low levels of the 5 X-linked genes. Low groups used as a baseline. The majority of the SKCM patients had no MAGEC3 expression and were, therefore, excluded from the analysis. (b) A Kaplan–Meier (KM) plot showing overall survival of KDM6A high vs. low group and (c) KDM6B high vs. low group in SKCM patients. RNA-seq data were retrieved from The Cancer Genome Atlas (TCGA) and stratified based on the median expression of KDM6A and KDM6B. Log-rank p-value < 0.05 refers to a significant association between gene expression and survival. Differential gene expression and survival of KDM6A based on sex: (d) KDM6A mRNA expression data were plotted based on sex. An unpaired t-test was done to assess the significance between the two sexes, and the p-value is represented as (*), where **** p < 0.0001. (e) The overall curve was plotted in GraphPad Prism for female and (f) male SKCM patients. Log-rank p < 0.05 refers to significance. Gene expression was dichotomized based on sex and corresponding median expression.