Table 1.
(a) Effect of gene-gene and gene-sex interaction on overall survival (OS) in SKCM cohort. Numbers representing the p-value where p < 0.05 refers to significant interaction on OS. (b) Effect of interaction on MSS in LMC (Validation cohort).
| (a) Effect of gene-gene and gene-sex interaction on OS in SKCM cohort | ||||
| Overall | KDM6A | ATRX | EZH2 | Sex |
| KDM6A | - | 0.983 | 0.033 | 0.96 |
| ATRX | - | 0.313 | 0.14 | |
| EZH2 | - | 0.02 | ||
| Sex | - | |||
| Primary | ||||
| KDM6A | - | 0.68 | 0.32 | 0.734 |
| ATRX | - | 0.878 | 0.971 | |
| EZH2 | - | 0.045 | ||
| Sex | - | |||
| Metastases | ||||
| KDM6A | - | 0.991 | 0.042 | 0.898 |
| ATRX | - | 0.25 | 0.115 | |
| EZH2 | - | 0.049 | ||
| Sex | - | |||
| (b) Effect of interaction on MSS in LMC (Validation cohort). | ||||
| Primary | KDM6A | ATRX | EZH2 | Sex |
| KDM6A | - | 0.05 | 0.03 | 0.41 |
| ATRX | - | 0.10 | 0.09 | |
| EZH2 | - | 0.02 | ||
| Sex | - | |||
Bold p-value refers to significance where, p < 0.05. Gene names are represented as italic.