Table 1.
Antimicrobial minimal inhibitory concentrations of the E. hormaechei subsp. hoffmanni.
| Antimicrobials | MIC (mg/L) (Clinical Categorization) |
|---|---|
| EUCAST Breakpoints i | |
| β-lactams | |
| Amoxicillin | >256 (R) |
| Amoxicillin + clavulanate a | >256 (R) |
| Ticarcillin | >256 (R) |
| Ticarcillin + clavulanate a | 64 (R) |
| Piperacillin | >256 (R) |
| Piperacillin + tazobactam b | 128 (R) |
| Temocillin | >32 (R) |
| Cefoxitin | >256 (R) |
| Aztreonam | >32 (R) |
| Cefotaxime | >32 (R) |
| Ceftazidime | >32 (R) |
| Ceftazidime + avibactam c | 8 (S) |
| Cefepime | >32 (R) |
| Cefepime + zidebactam d | 8 |
| Ceftolozane + tazobactam b | >32 (R) |
| Ertapenem | >32 (R) |
| Imipenem | 8 (R) |
| Imipenem + relebactam e | 1 (S) |
| Meropenem | 16 (R) |
| Meropenem + vaborbactam f | 8 (S) |
| Cefiderocol g | 1 (S) |
| Aminoglycosides | |
| Gentamicin | >256 (R) |
| Tobramycin | 48 (R) |
| Amikacin | 16 (R) |
| Quinolones | |
| Levofloxacine | >32 (R) |
| Ciprofloxacine | >32 (R) |
| Cyclines | |
| Tigecycline h | 1 (S) |
| Eravacycline h | 2 (S) |
| Other | |
| Sulfamethoxazole-trimethoprim | >32 (R) |
| Chlorampenicol | >256 (R) |
| Colistin | 0.5 (S) |
MIC: minimal inhibitory concentration; S: Susceptible; I: Intermediate; R: Resistant. a clavulanate concentration is fixed at 2 mg/L. b tazobactam concentration is fixed at 4 mg/L. c avibactam concentration is fixed at 4 mg/L. d cefepime/zidebactam ratio is (1:1). e relebactam concentration is fixed at 4 mg/L. Breakpoints of imipenem alone were used for clinical categorization. f vaborbactam concentration is fixed at 8 mg/L. g MIC was determined using iron-depleted, cation-adjusted Mueller-Hinton broth. h Tetracycline breakpoints were used for clinical categorization. i Clinical categorization was determined using EUCAST breakpoints as updated in 2020 (https://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_tables/v_10.0_Breakpoint_Tables.pdf).