Table 2.
Expression levels of ZKSCAN3 in radical prostatectomy specimens.
| n | Levels of ZKSCAN3 Expression | p | IHC Score (mean ± SD) |
p (t-Test) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1+ | 2+ | 3+ | 1+/2+/3+ | 0 vs. 1+/2+/3+ | 0/1+ vs. 2+/3+ | 0/1+/2+ vs. 3+ | ||||
| Benign | 150 | 99 (66%) | 44 (29%) | 6 (4%) | 1 (1%) | 51 (34%) | <0.001 *1 | <0.001 *1 | 0.301 *1 | 1.65 ± 1.41 | <0.001 *1 |
| HGPIN | 146 | 54 (37%) | 68 (47%) | 21 (14%) | 3 (2%) | 92 (63%) | <0.001 *2 | <0.001 *2 | <0.001 *2 | 2.58 ± 1.66 | <0.001 *2 |
| Carcinoma | 300 | 21 (7%) | 99 (33%) | 95 (32%) | 85 (28%) | 279 (93%) | <0.001 *3 | <0.001 *3 | <0.001 *3 | 5.20 ± 2.33 | <0.001 *3 |
| Age (mean ± SD, year) | 300 | 58.0 ± 4.8 | 60.2 ± 6.4 | 60.2 ± 6.1 | 60.8 ± 6.1 | 60.4 ± 6.2 | 0.079 | 0.363 | 0.275 | NA | |
| PSA (mean ± SD, ng/mL) | 300 | 5.72 ± 3.27 | 6.02 ± 3.07 | 7.21 ± 4.88 | 6.44 ± 3.87 | 6.31 ± 3.91 | 0.441 | 0.243 | 0.623 | NA | |
| Gleason score (GS)/Grade Group (GG) | |||||||||||
| GS ≤ 6/GG 1 | 107 | 11 (10%) | 32 (30%) | 44 (41%) | 20 (19%) | 96 (90%) | 0.097 *4 | 0.961 *4 | 0.006 *4 | 4.91 ± 2.15 | 0.099 *4 |
| GS 3 + 4 = 7/GG 2 | 127 | 9 (7%) | 52 (41%) | 36 (28%) | 30 (24%) | 118 (93%) | 0.048 *5 | 0.003 *5 | <0.001 *5 | 4.85 ± 2.34 | <0.001 *5 |
| GS 4 + 3 = 7/GG 3 | 46 | 1 (2%) | 11 (24%) | 9 (20%) | 25 (54%) | 45 (98%) | 0.204 *6 | 0.059 *6 | 0.026 *6 | 6.26 ± 2.28 | 0.010 *6 |
| GS ≥ 8/GG 4–5 | 20 | 0 (0%) | 4 (20%) | 6 (30%) | 10 (50%) | 20 (100%) | 6.50 ± 2.09 | ||||
| Pathologic stage (pT) | |||||||||||
| 2 | 235 | 15 (6%) | 88 (37%) | 79 (34%) | 53 (23%) | 220 (94%) | 0.426 *7 | 0.010 *7 | <0.001 *7 | 4.95 ± 2.19 | <0.001 *7 |
| 3a | 47 | 6 (13%) | 9 (19%) | 13 (28%) | 19 (40%) | 41 (87%) | 0.230 *8 | 0.010 *8 | <0.001 *8 | 5.51 ± 2.58 | <0.001 *8 |
| 3b | 18 | 0 (0%) | 2 (11%) | 3 (17%) | 13 (72%) | 18 (100%) | 7.61 ± 1.90 | ||||
| Lymph node metastasis (pN) | 0.326 | 0.075 | 0.021 | 0.002 | |||||||
| 0 | 154 | 15 (10%) | 48 (31%) | 45 (29%) | 46 (30%) | 139 (90%) | 5.05 ± 2.46 | ||||
| 1 | 9 | 0 (0%) | 1 (11%) | 2 (22%) | 6 (67%) | 9 (100%) | 7.67 ± 1.94 | ||||
| History of vasectomy | 0.293 | 0.044 | 0.217 | 0.018 | |||||||
| No | 286 | 21 (7%) | 97 (34%) | 89 (31%) | 79 (28%) | 265 (93%) | 5.13 ± 2.33 | ||||
| Yes | 14 | 0 (0%) | 2 (14%) | 6 (43%) | 6 (43%) | 14 (100%) | 6.64 ± 1.79 | ||||
*1 Benign vs. HGPIN. *2 HGPIN vs. Carcinoma. *3 Benign vs. Carcinoma. *4 GG1 vs. GG2-5. *5 GG1-2 vs. GG3-5. *6 GG1-3 vs. GG4-5. *7 pT2 vs. pT3. *8 pT2/pT3a vs. pT3b.