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. 2020 Aug 14;12(8):2279. doi: 10.3390/cancers12082279

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Biodistribution of SDC1-Lip in orthotopic pancreatic tumor models using multispectral optoacoustic tomography (MSOT). Biodistribution of SDC1-Lip was assessed using MSOT in (A) S2VP10 (B) and S2CP9 mouse models. (C) After 8h, S2VP10 tumor accumulation was 17.7 a.u, liver 5.7 a.u., and kidney 2.7 a.u. (D) After 8 h, S2CP9 tumor accumulation was 17.0 a.u, liver 1.5 a.u., and kidney 0.5 a.u. IR780 accumulation in S2VP10 and S2CP9 pancreatic tumors was significantly increased compared to liver and kidneys (S2VP10 p = 0.0016, p = 0.00004 and S2CP9 p = 0.0009, p = 0.00006). (E) Ex vivo NIR fluorescent imaging further demonstrates highest uptake of SDC1-Lip within pancreatic tumor (T) when compared to the liver (L), kidney (K), or spleen (S). * p < 0.05 significance.