Skip to main content
. 2020 Aug 14;12(8):2283. doi: 10.3390/cancers12082283

Table 2.

Molecular data and outcome of the 13 patients enrolled in the trial.

Patient Gene MMR Mutations MSI TMB (muts/Mb) PD-L1 (% Tumor Cells) MHC-1 (% Tumor Cells) Macrophage Density (n/mm2) CD8+ Density (n/mm2) Response PFS (Months) OS (Months)
1PD * none absent 13.4 0 40 360.20 8.10 SD 5.29 9.00
2PD none absent 7.7 0 75 605.20 20.00 PD 1.12 1.68
3PD * none absent 9.78 0 30 971.20 45.40 PD 0.92 1.68
4PD * none absent 10.26 0 95 680.60 11.80 PD 2.37 3.61
5PD none absent 13.28 0 0 108.90 21.20 PD 1.54 29.40 °
9PD none absent 8.45 0 0 140.10 38.80 PD 0.69 1.15
10PD none absent 13.93 3 70 454.70 84.90 SD 7.36 19.98
12PD * none absent 6.76 0 50 328.00 0.00 PD 2.23 2.76
13_1PD none absent 10.84 5 70 393.00 90.70 PD 1.84 18.20 °
16PD none absent 8.97 0 0 256.79 3.75 SD 16.76 21.36
17PD MSH6 absent 26.89 0 90 483.10 30.60 PD 2.14 2.79
18PD none absent 9.33 0 95 665.30 52.00 SD 8.11 23.13 °
21PD n.d. n.d. n.d. 0 n.d. n.d. n.d. PD 3.09 5.59

* In these cases, histological and molecular analyses were performed on primary tumors, in all other cases on recurrent tumors (all pts received temozolomide and RT as first treatment); °: censored; n.d.: not done; SD: stable disease; PD: progressive disease. MMR: mismatch repair; MSI: microsatellite instability; TMB: tumor mutational burden; PFS: progression-free survival; OS: overall survival.