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. 2020 Aug 5;9(8):994. doi: 10.3390/plants9080994

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of increasing concentrations of Nj, Vo and Vj EOs on cortical neuron networks activity. Nj EO showed a concentration-dependent inhibition for both mean firing rate (MFR) (A) and mean burst rate (MBR) (B), with IC₅₀ values of 12.8 and 11.1 µg/mL, respectively (n = 6). The EO of Vo showed similar but less strong effects on MFR (C) and MBR (D), with IC₅₀ values of 16.0 and 22.2 µg/mL, respectively (n = 5). Vj EO was the less effective to induce the inhibition of neuronal activity with IC₅₀ values of 54.4 and 88.7 µg/mL for MFR (E) and MBR (F), respectively. * p < 0.05.