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. 2020 Aug 7;12(8):2216. doi: 10.3390/cancers12082216

Figure 1.

Figure 1

Schematic representation of spliceosome complexes. (A) Representation of U1 snRNP, U2 snRNP and auxiliary factors fixation on pre-mRNA (major spliceosome). U1 snRNP recognizes the 5′-splice site. U2snRNP recognizes the 3′-splice site at conserved sequence positions: the branch-point, the poly-pyrimidine-tract (Py-tract), and the AG dinucleotide thanks to SF3B1 in SF3B complex, U2AF2 and U2AF1 respectively. SRSF2 binds to exonic splicing enhancer (ESE) to favor recognition and fixation of U1 and U2 snRNP. ZRSR2 promotes major spliceosome assembly. (B) U1 snRNP and U2 snRNP joining allows the 5′-splice site to interact with the branch point. (C) U11 and U12 snRNP belong to the minor spliceosome that is involved in U12-intron splicing. U12-introns are delimited by sequences at 5′ (GU or AU) and 3′ (AG or AC) splice sites different from those present in U2-introns. ZRSR2 promotes minor spliceosome assembly.