Table 1.
Gene | Mutation Frequency (n/N) | References | ||||
---|---|---|---|---|---|---|
PMF | SMF | ET | PV | AML Post MPN | ||
SRSF2 | 12.2% (351/2876) Pre-MF: 8.5% (25/294) |
2.6% (12/461) | 1.5% (31/2132) | 1.8% (22/1244) | 17% (25/147) | [24,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61] |
SF3B1 | 7.7% (135/1751) | 6.9% (8/116) | 2.8% (62/2207) | 1.4% (14/1027) | 8.1% (13/161) | [45,46,47,48,49,50,51,53,55,56,57,58,59,60,61,62,63,64] |
U2AF1 | 13.8% (200/1448) | 4.9% (5/102) | 1.1% (23/2132) | 0.3% (3/969) | 9.5% (14/147) | [46,47,48,49,50,53,55,56,57,58,59,60,61] |
ZRSR2 | 5.8% (52/891) | 6.9% (7/102) | 0.7% (11/1590) | 1.3% (7/535) | 1.1% (1/91) | [46,47,48,55,56,57,58,59,61] |
PRPF8 | 2.1% (2/94) | 1.6% (1/64) | 2.9% (1/35) | 0% (0/8) | 5.3% (5/94) | [48,50,59] |