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. 2020 Aug 7;12(8):2216. doi: 10.3390/cancers12082216

Table 1.

Spliceosomal mutations in MPN and AML post-MPN patients.

Gene	Mutation Frequency (n/N)					References
Gene	PMF	SMF	ET	PV	AML Post MPN	References
SRSF2	12.2% (351/2876) Pre-MF: 8.5% (25/294)	2.6% (12/461)	1.5% (31/2132)	1.8% (22/1244)	17% (25/147)	[24,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61]
SF3B1	7.7% (135/1751)	6.9% (8/116)	2.8% (62/2207)	1.4% (14/1027)	8.1% (13/161)	[45,46,47,48,49,50,51,53,55,56,57,58,59,60,61,62,63,64]
U2AF1	13.8% (200/1448)	4.9% (5/102)	1.1% (23/2132)	0.3% (3/969)	9.5% (14/147)	[46,47,48,49,50,53,55,56,57,58,59,60,61]
ZRSR2	5.8% (52/891)	6.9% (7/102)	0.7% (11/1590)	1.3% (7/535)	1.1% (1/91)	[46,47,48,55,56,57,58,59,61]
PRPF8	2.1% (2/94)	1.6% (1/64)	2.9% (1/35)	0% (0/8)	5.3% (5/94)	[48,50,59]