Figure 5.

Effects of probiotic strains on cytokine secretion by MoDC derived from HD, UC and CD patients infected with AIEC-LF82 strain. Secretion of IL-1β (A), IL-23 (B), IL-12 (C) and IL-10 (D) in the supernatants of MoDC derived from HD, UC patients or CD patients after 24 h of infection with AIEC-LF82 alone or in the presence of either Lactobacillus strains (+L₁ or +L₂) or Bifidobacterium strains (+B₁ or +B₂) or S. epidermidis ATCC-155 (+S.e.), at 1:1 ratio or in the presence of 6MP (2 µg/mL), was quantified by ELISA. Dot lines (---) represent the median values for cytokine secretion of MoDC infected with LF82 alone. Data are represented as described in Figure 1. Statistical significance for each condition compared to MoDC infected with LF82 alone was reported (* p < 0.05, ** p < 0.01, *** p < 0.001).