Figure 6.

EGFR regulates oligodendrogenesis and neurite outgrowth. (A) EGFR overexpression stimulates oligodendrocyte precursor cells to differentiate into myelinating oligodendrocytes, highlighting its important role in oligodendrogenesis. (B) Axon engagement, which represents the final step of oligodendrocytes maturation, is stimulate by EGFR inhibition. (C) Microglia in the corpus callosum produce chitinase-3-like-3 which activates EGFR expressed by NSCs in the near SVZ. This leads to MEK/ERK pathway activation that promotes oligodendrogenesis. (D) EGFR activates AKT and ERK signaling pathways which are important for neurite outgrowth.