Figure 6.

Schematic representation of proposed mechanism of action of miR-302b and cisplatin in TNBC cells. Upper scheme represents the biological activity of miR-302b in monotherapy. Exogenous expression of miR-302b does not affect ITGA6, since YY1 can interact with E2F2 to maintain ITGA6 transcription. Lower scheme represents the effect of combined intervention of miR-302b and cisplatin, that results in YY1 and E2F2 down-modulation impeding their activity over ITGA6 and leading to TNBC cell death. This proposed mechanism acts together with the well-known E2F1 down-modulation, another predicted ITGA6 TF, by miR-302b.