Figure 7.

Quantitative real-time PCR data. Graphical presentation of gene transcript levels of M₁ markers (Il23a, Il12b, and Tnfa) and of M₂ markers (Vegfa, Tgfb1, and Il10) in samples treated with LPS (500 ng/mL) and either treated with culture media (IC,U, blue), free dexamethasone (free Dx, 5.1 μM, red), Dx-loaded ketoprofen-bearing NPs (14Dx-KT NPs, 5.1 μM Dx and 0.045 mg/mL NPs, white), and unloaded ketoprofen-bearing NPs (KT NPs, 0.045 mg/mL, black) for 1 day (plain) or 7 days (dashed). Results were expressed relative to the corresponding level of expression of each transcript in non-inflammatory conditions (RAW264.7 alone, NIC). The diagrams include the mean, the standard deviation (n = 2), and the ANOVA results (#—comparison with IC,U control, # p < 0.05, ## p < 0.01, and ### p < 0.001; *—comparison between systems, * p < 0.05 and ** p < 0.01).