Table 8.
Comparison of mutual occurrence of dysfunctional variants of ABCG2 (p.Q141K, p.R147W, p.T153M, p.F373C, p.T434M, p.S476P, and p.S572R) and the variant p.350L in a cohort of individuals with hyperuricemia and gout.
| Without ABCG2 Variants (Number) | Without ABCG2 Variants (%) | Occurrence of Variants of ABCG2 (Number) | Occurrence of Variants of ABCG2 (%) | Total Number (without Distinction of Alleles of ABCG2) | Portion in the Whole Cohort (%) | ||
|---|---|---|---|---|---|---|---|
| p.P350L | wild type + heterozygotes | 175 | 72 | 2 | 28.6 | 177 | 70.8 |
| homozygotes | 68 | 28 | 5 | 71.4 | 73 | 29.2 | |
| total in the given column | 243 | 100 | 7 | 100.0 | 250 | 100.0 | |
Fisher’s Exact Test: p-value = 0.0239, odds ratio 6.38.