Figure 1.

Dietary supplementation of grape antioxidants quercetin and resveratrol inhibit tumor development and progression in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) model. (a) Preclinical study design and the timeline for prevention and intervention settings in TRAMP mice. (b) Representative images of tumors with scale bar showing the size of tumors at the termination of study in prevention setting. (c) Graphical representation of tumor wet weight data in prevention setting. (d) Representative images of tumors with scale bars in the intervention setting. (e) Tumor wet weight data in the intervention setting. The tumor data are represented as mean ± SEM of 12 animals per group. GraphPad Prism 5 Software was used to perform statistical analyses on tumor data using one-way analysis of variance (ANOVA) followed by uncorrected Fisher’s Least Significant Difference (LSD) test (* p < 0.05).