A
| Compounds | IC50 (μM ± SD) | |||||
|---|---|---|---|---|---|---|
| HeLa | MDA-MB-231 | MDA-MB-468 | MCF7 | 184B5 | MCF 10A | |
| Oxostephanine 1 | 1.76 ± 0.20 | 2.67 ± 0.29 | 2.26 ± 0.54 | 4.35 ± 1.20 | 1.66 ± 0.56 | 2.49 ± 0.11 |
| Thailandine 2 | 4.10 ± 0.40 | 7.11 ± 0.07 | 0.78 ± 0.12 | 1.99 ± 1.36 | 3.02 ± 0.10 | 5.01 ± 0.15 |
| Stephanine 3 | 3.33 ± 0.23 | 5.66 ± 0.16 | 7.14 ± 2.11 | 6.49 ± 0.43 | 6.25 ± 0.14 | 7.19 ± 0.33 |
| Crebanine 4 | 48.13 ± 2.38 | 38.94 ± 7.10 | 17.82 ± 4.63 | 30.50 ± 4.89 | 47.44 ± 2.83 | 47.16 ± 4.37 |
| O-methylbulbocapine 5 | 70.37 ± 11.40 | 56.59 ± 9.08 | 48.13 ± 1.69 | 39.36 ± 6.20 | 73.26 ± 0.47 | 59.47 ± 1.90 |
| Palmatine chloride 6 | >100 | >50 | >50 | >50 | >50 | >50 |
| Tetrahydropalmatine 7 | >50 | >50 | >50 | >50 | >50 | >50 |
| Chloroquine | 29.80 ± 0.70 | 28.90 ± 0.40 | 33.20 ± 0.40 | >50 | >50 | 40.50 ± 9.80 |
| Paclitaxel a | 3.81 ± 0.42 | 1.58 ± 0.75 | 3.96 ± 0.32 | 2.71 ± 1.11 | 2.65 ± 1.91 | 1.67 ± 0.21 |
a Paclitaxel with IC50 in nM. Chloroquine and paclitaxel are positive controls.