Representative SEM micrographs of irradiated electrospun PLGA after immersion in SBF, DMEM and saliva for 7, 15 and 30 days. Scale bars: (A–I) = 5 µm; (a–i) = 1 µm. Membrane immersed in SBF for 7 days showed fibers with border fissures. (a, arrow); Elongated fissures were seen in different regions of fibers after 15 days of immersion in SBF (b, white arrow) and also erosion areas (b, black arrow); after 30 days of immersion in SBF, fibers became in more contact to each other (C, c, asterisk). Morphology of fibers after immersion in DMEM for 7 days shows different directions of fibers and connections to each other (d, asterisk); After 15 days of immersion in DMEM, fibers showed surface fissures (e, white arrow) and erosion areas (e, black arrow). Morphology of fibers after 30 days of immersion in DMEM showed coalescence areas (F,f, white asterisks) and also connected fibers (F, black asterisks). Fibers showed border fissures after 7 days of immersion in saliva (g, white arrow); after 15 days, fibers showed increased border and surface fissures (h, white arrow) and erosion areas (h, black arrow); after 30 days of immersion in saliva, fibers showed scarce border fissures (i, white arrow), coalescence areas among fibers (I, white asterisks) and also fibers junctions (I,i, black asterisks).