Table 4.
Lung Cancer Major Subtype Risks Associated with Cumulative Occupational Silica Exposure
| Cumulative Exposure (mg/m3-years) | Adenocarcinoma |
Squamous Cell Carcinoma |
Small Cell Carcinoma |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases (n) | OR* | 95% CI | Cases (n) | OR* | 95% CI | Cases (n) | OR* | 95% CI | |
| Never | 3,683 | 1.0 | Referent | 4,252 | 1.0 | Referent | 1,861 | 1.0 | Referent |
| >0–0.39 | 283 | 1.14 | 0.98–1.33 | 455 | 1.22 | 1.06–1.39 | 194 | 1.07 | 0.89–1.28 |
| 0.4–1.09 | 282 | 1.18 | 1.02–1.37 | 557 | 1.51 | 1.33–1.71 | 204 | 1.41 | 1.17–1.68 |
| 1.1–2.39 | 240 | 1.03 | 0.88–1.20 | 593 | 1.46 | 1.29–1.65 | 229 | 1.48 | 1.25–1.76 |
| ≥2.4 | 264 | 1.17 | 1.00–1.37 | 646 | 1.55 | 1.37–1.76 | 242 | 1.70 | 1.43–2.02 |
| Test for trend, P value | 0.01 | <0.01 | <0.01 | ||||||
| P value excluding never exposed | 0.02 | <0.01 | <0.01 | ||||||
Definition of abbreviations: CI = confidence interval; OR = odds ratio.
*
OR adjusted for study, age group, sex, smoking (pack-years, time since quitting smoking), and list A jobs.