Table 7.
Interactions between Occupational Silica Exposure and Smoking for Major Lung Cancer Subtypes
| Exposure Status | Adenocarcinoma |
Squamous Cell Carcinoma |
Small Cell Carcinoma |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases (n) | OR* | 95% CI | Cases (n) | OR* | 95% CI | Cases (n) | OR* | 95% CI | |
| Never-smoker and never silica | 589 | 1.0 | Referent | 195 | 1.0 | Referent | 82 | 1.0 | Referent |
| Never-smoker and ever silica | 111 | 1.01 | 0.81–1.24 | 62 | 1.22 | 0.90–1.62 | 29 | 1.49 | 0.96–2.27 |
| Ever-smoker and never silica | 3,094 | 3.90 | 3.52–4.32 | 4,057 | 11.0 | 9.47–12.8 | 1,779 | 13.6 | 10.9–17.3 |
| Ever-smoker and ever silica | 958 | 4.61 | 4.06–5.23 | 2,189 | 16.1 | 13.7–18.9 | 840 | 19.2 | 15.3–24.7 |
| P value multiplicative interaction | 0.17 | 0.23 | 0.80 | ||||||
| RERI | 0.70 | 0.26–1.15 | 4.86 | 3.63–6.09 | 5.13 | 3.03–7.23 | |||
For definition of abbreviations, see Table 6.
*
OR adjusted for sex, study, age group, and list A jobs.