Table 3.

Lung Cancer Major Subtype Risks Associated with Cumulative Occupational EC Exposure in Men

Cumulative EC Exposure, μg/m3-years by Lung Cancer Subtypes	Cases	OR*	95% CI
Adenocarcinoma
Never	1,513	1.0	Referent
>0–22	414	1.09	0.95–1.24
23–70	415	1.00	0.88–1.14
71–178	452	1.07	0.94–1.21
>178	531	1.23	1.09–1.39
Test for trend, P value†	—	0.14	—
P value excluding never exposed‡	—	0.49	—
Large cell carcinoma
Never	257	1.0	Referent
>0–22	84	1.04	0.79–1.36
23–70	76	0.90	0.68–1.18
71–178	93	1.14	0.88–1.47
>178	109	1.31	1.02–1.67
Test for trend, P value†	—	0.11	—
P value excluding never exposed‡	—	0.14	—
Squamous cell carcinoma
Never	2,216	1.0	Referent
>0–22	742	1.13	1.01–1.26
23–70	819	1.14	1.03–1.27
71–178	982	1.37	1.24–1.52
>178	1,069	1.54	1.39–1.70
Test for trend, P value†	—	<0.01	—
P value excluding never exposed‡	—	0.01	—
Small cell carcinoma
Never	850	1.0	Referent
>0–22	249	0.99	0.84–1.16
23–70	334	1.20	1.03–1.39
71–178	360	1.31	1.14–1.53
>178	407	1.53	1.32–1.76
Test for trend, P value†	—	0.02	—
P value excluding never exposed‡	—	0.39	—

For definition of abbreviations, see Table 2.

^*ORs adjusted for study, age group, smoking pack-years [log(cigarette pack-years + 1)], time since quitting smoking, and list A jobs.

^†Test for trend, P value obtained using the corresponding continuous exposure variable.

^‡Test for trend, P value obtained using the corresponding continuous exposure variable among exposed subjects only.