. 2020 Jul 24;12(8):2025. doi: 10.3390/cancers12082025

Table 1.

MiRNAs and their targets in tumor-immune communication.

miRNAs	Target Genes	Function	Cancer Type	Expression	Reference
miR-181a/b, miR-498	TNFα	Reduces the cytotoxicity of CD8 T cells	Melanoma	Exosomes	[15]
miR-3187-3p	PTPRC	Inhibition of TCR signaling	Melanoma		[15]
miR-23a-3p	PTEN	Induces PD-L1 expression in macrophages	Hepatocellular carcinoma		[16]
miR-29a-3p, miR-21-5p	STAT3	Induces a higher Treg/Th17 cell ratio	TAM (Tumor-associated macrophages)		[17]
miR-298-5p	Unknown	Induces apoptosis of MSCs via Caspase-3	Fibrosarcoma		[18]
miR-448	IDO1	Enhance CD8 T cell survival	Colorectal cancer	Tumor cells	[27]
miR-153	IDO1	Enhance CD8 T cell survival	Colorectal cancer		[28]
miR-34a	PDL1	Blocks the PD-1 pathway	Burkitt lymphoma, DLBCL		[36]
miR-BHRF1-2-5p	PDL1, PDL2	Blocks the PD-1 pathway	EBV-positive DLBCL		[37]
miR-708	CD47	Promotes tumor cell elimination by phagocytosis	T-ALL		[42]
miR-155	CD47	Promotes tumor cell elimination by phagocytosis	MM		[43]
miR-122	BCL9, AMPK, PI3K/AKT, Wnt/β-catenin	Inhibits metastasis and proliferation	Hepatocellular carcinoma		[53,54]
miR-203	POLA1, HBEGF	Limits proliferation of skin cells	Squamous cell carcinoma		[55]
miR-450a	ACO2, TIMMDC1, ATP5B, MT-ND2	Limits tumor formation and progression	Ovarian cancer		[57]