Table 1.
Baseline Demographic and Disease Characteristics
| Characteristic | Isradipine (n = 170) | Placebo (n = 166) |
|---|---|---|
| Mean age (SD), y | 62.1 (8.7) | 61.6 (9.3) |
| Men, n (%) | 122 (71.8) | 108 (65.1) |
| Non-Hispanic white race, n (%) | 156 (91.8) | 146 (88.0) |
| Mean disease duration from diagnosis (SD), mo | 9.9 (8.1) | 10.6 (9.3) |
| Family history of PD (first-degree relatives), n (%) | 30 (17.6) | 35 (21.1) |
| Left-handed, n (%) | 20 (11.8) | 19 (11.4) |
| Receiving symptomatic therapy, n (%) | ||
| Amantadine | 15 (8.8) | 11 (6.6) |
| Anticholinergics | 3 (1.8) | 2 (1.2) |
| Mean UPDRS score (SD) | ||
| Total | 23.7 (8.6) | 22.6 (8.5) |
| Part I (mental) | 0.6 (0.9) | 0.8 (1.2) |
| Part II (ADL) | 5.0 (2.9) | 5.4 (3.3) |
| Part III (motor) | 18.1 (7.3) | 16.3 (6.5) |
| PIGD | 0.2 (0.2) | 0.2 (0.2) |
| Tremor | 0.5 (0.3) | 0.5 (0.3) |
| Mean Hoehn and Yahr stage (SD) | 1.7 (0.5) | 1.6 (0.5) |
| Mean Schwab and England ADL scale score (SD) | 94.4 (5.2) | 94.0 (6.8) |
| Mean modified Rankin score (SD) | 1.1 (0.3) | 1.1 (0.3) |
| Mean Montreal Cognitive Assessment score (SD) | 28.1 (1.4) | 28.0 (1.3) |
| Mean Beck Depression Inventory total score (SD) | 4.1 (3.7) | 4.8 (4.3) |
| Mean PDQ-39 total score (SD) | 7.1 (6.1) | 9.1 (8.5) |
| Mean systolic blood pressure (SD), mm Hg* | 128.1 (17.2) | 127.7 (14.6) |
| Mean diastolic blood pressure (SD), mm Hg* | 76.5 (9.7) | 77.8 (8.5) |
ADL = activities of daily living; PD = Parkinson disease; PDQ-39 = 39-item Parkinson’s Disease Questionnaire; PIGD = postural instability and gait disorder; UPDRS = Unified Parkinson’s Disease Rating Scale.
*
Measured while patient was seated.