Table 2.

Studies investigating differential expression of microRNAs in ACC Tissues compared with ACA and NAC.

Year of Publication	Methodology	Tissue Samples	Upregulated miRNA		Downregulated miRNA		Reference
2009	TLDA	7 ACC, 19 ACA, 10 NAC	miR-184 miR-210 miR-503		miR-214 miR-511 miR-375		[78]
2009	Microarray VC: RT-q-PCR	22 ACC, 27 ACA, 6 NAC VC (10 ACC, 9 ACA)	miR-483-5p miR-503		miR-7 miR-195	miR-335	[73]
2011	Microarray VC: RT-q-PCR	25 ACC, 43 ACA, 10 NAC	miR-483-3p miR-483-5p	miR-210 miR-21	miR-195 miR-497		[74]
2011	Microarray VC: RT-q-PCR	10 ACC, 26 ACA VC (31 ACC, 35 ACA, 21 NAC)	miR-483-5p		miR-195 miR-125b	miR-100	[75]
2011	TLDA VC: RT-q-PCR	7 ACC, 9 ACA, 4 NAC VC (16 ACC)	miR-139-5p		miR-139-3p miR-675	miR-335	[79]
2013	Microarray	12 ACC, 6 NAC VC (18 ACC, 10 ACA, 3 NAC)	miR-483-5p miR-503 miR-210 miR-542-5p	miR-320a miR-93 miR-148b	miR-195 miR-335 miR-497	miR-199a-5p miR-199a-3p	[76]
2014	RT-q-PCR	51 ACC, 47 ACA	miR-483-3p miR-483-5p miR-210		miR-195		[80]
2014	RNA sequencing	45 ACC, 3 NAC	miR-34b-5p miR-410 miR-483-3p miR-483-5p miR-503	miR-506-3p miR-506-5p miR-508-3p miR-508-5p miR-510	miR-511 miR-214-3p miR-485-3p miR-497 miR-195		[51]
2015	Microarray VC: RT-q-PCR	8 ACC, 25 ACA VC (11 ACC, 4 ACA)	miR-503		miR-34a	miR-497	[77]
2016	RNA sequencing	79 ACC, 120 NAC	miR-10-5p miR-483-5p miR-22-3p miR-508-3p miR-509-3p	miR-509-5p miR-340 miR-146a miR-21-3p miR-21-5p			[81]
2017	RNA sequencing	7 ACC, 8 ACA, 8 NAC VC (8 ACC, 10 ACA, 10 NAC)	miR-503-5p miR-450a-5p miR-542-5p miR-483-3p miR-542-3p miR-450b-5p miR-210 miR-483-5p	miR-421 miR-424-3p miR-424-5p miR-598 miR-148b-3p miR-184 miR-128			[72]

TLDA, TaqMan Low Density Array; VC, Validation Cohort; ACC, adrenocortical carcinoma; ACA, adrenal adenoma; NAC, normal adrenal cortex.