Table 3.
Overexpressed microRNAs and their regulated targets in ACC.
| microRNA | Functional Role in ACC | Molecular Target | Evidence for Regulatory Interaction | Reference/s |
|---|---|---|---|---|
| miR-9 | Associated with reduced DFS and increased recurrence in clinical data | LIN28 | Weak protein expression pattern in aggressive ACC Established reporter assays in non-ACC models |
[109,110,111] |
| miR-21 | ↑ cellular proliferation | PCDC4 | Inverse correlation in expression Reporter assays in non-ACC cell models |
[112,113,114,115] |
| miR-139-5p | Associated with anchorage-independent colony formation | NDRG4 | Inverse correlation in expression Reporter assays in non-ACC cell models |
[116] |
| miR-483-3p | ↑ cellular proliferation ↓ apoptosis |
PUMA | Inverse correlation in expression Reporter assays in non-ACC models |
[74,117] |
| miR-483-5p | Associated with anchorage-independent colony formation | NDRG2 | Inverse correlation in expression Reporter assays in non-ACC models |
[116] |
DFS, Disease-Free Survival; PDCD4, Programmed cell death protein 4; NDRG, N-myc downstream-regulated gene; PUMA, p53 upregulated modulator of apoptosis.