Table 3.

DNases that targets extracellular proteins. Supplemented and modified based on information provided in [6].

Name	Summary	References
DNase I	It has been demonstrated that pancreatic deoxyribonuclease (DNase) can deconstruct the established biofilms of a wide range of microbes, including P. aeruginosa, Vibrio cholerae, E. coli, S. pyogenes, Klebsiella pneumoniae, Acinetobacter baumannii, Aggregatibacter actinomycetemcomitans, Shewanella oneidensis, S. heamolyticus, Bordetella pertussis, Bordetella bronchiseptica, Campylobacter jejuni, H. influenza, B. bacteriovorus, S. aureus, Enterococcus faecalis, L. monocytogenes, Candida albicans, and Aspergillus	[74]
λ Exonuclease	A kind of viral DNase that can disrupt established V. cholerae biofilms.	[80]
DNase1L2	A human DNase found in keratinocytes that has been demonstrated to degrade the established biofilms of P. aeruginosa and S. aureus.	[81]
Dornase alpha	A highly purified form of recombinant human DNase I (rhDNase I), which has been demonstrated to be effective against the established biofilms of S. aureus, G. vaginalis and Streptococcus pneumoniae.	[72,78,82,83]
NucB	A bacterial DNase produced by the marine bacterium, Bacillus licheniformis, which has been shown to be able to degrade the established biofilms of multiple bacterial species, including B. licheniformis, S. aureus, S. epidermidis, Staphylococcus salivarius, Staphylococcus constellatus, S. Staphylococcus lugdunesis, Staphylococcus anginosus, E. coli, Streptococcus intermedius, Micrococcus luteus, and Bacillus subtilis.	[84,85,86]
Streptodornase	A streptococcal DNase that can disrupt the established biofilms of P. aeruginosa.	[87]