Table 7.

Molecules that targeting quorum sensing (QS) systems.

Name	Summary	References
AI-2	QS autoinducer, functions as a chemorepellent in Helicobacter pylori by regulating the proportion and spatial organization of biofilm cells and has been proved to effectively reduce the proportion of adherent cells and induce biofilm dispersal.	[214]
AIP-I	The autoinducing peptide type I activates a regulatory cascade called agr system, resulting in the increased expression of invasive factors, including toxins, hemolysins, proteases, and other tissue-degrading enzymes. It has been proved to effectively disrupt biofilm formed by MRSA.	[220]
RIP	RNAIII-inhibiting peptide, a heptapeptide that has been shown to inhibit the biofilms formation of both methicillin-resistant and vancomycin-resistant S. aureus and S. epidermidis.	[221,222,223,224,225,226]
M64	A small molecule that target the MvfR-regulated QS virulence pathway, which can effectively silence the MvfR communication system, thus blocks P. aeruginosa virulence both in vitro and in vivo.	[227]
Cinnamic acid	Acts as a competitive inhibitor for the natural ligands towards the ligand binding domain of the transcriptional activators of the quorum sensing circuit in P. aeruginosa, LasR and RhlR. It has been proved to effectively inhibit both the production of the QS-dependent virulence factors and biofilm formation in P. aeruginosa.	[228]
Trans 4-(2-carboxy-vinyl) benzoic acid	Cell-free extracts of Natrinema versiforme which show QSI properties against P. aeruginosa and is efficient for biofilm inhibition.	[229]
SM23	A boronic acid derivative of β-lactamase inhibitor, acting as a powerful inhibitor of P. aeruginosa biofilm.	[230]