Table 1.
Descriptive statistics of CD105- and CD31-assessed microvessel density (MVD) (biopsies and surgical specimens) and of conventional clinical-pathological features according to laryngeal squamous cell carcinoma (LSCC) recurrence, and univariable Cox regression analysis results for LSCC recurrence.
| No. = 45 | Without LSCC Recurrence (No. = 31) | With LSCC Recurrence (No. = 14) | * p-Value | HR (95%CI) |
|---|---|---|---|---|
| CD105 MVD (biopsy) | ||||
| Mean (SD) | 1.56 (3.47) | 10.98 (4.86) | ||
| Median (IQR) | 0.00 (0.00–2.34) | 11.84 (8.00–15.00) | <0.0001 | 1.221 (1.118; 1.334) |
| CD31 MVD (biopsy) | ||||
| Mean (SD) | 4.36 (3.85) | 12.36 (4.65) | ||
| Median (IQR) | 3.34 (2.34–5.34) | 13.84 (8.67–15.67) | <0.0001 | 1.202 (1.107; 1.306) |
| CD105 MVD (surgical specimen) | ||||
| Mean (SD) | 3.05 (5.68) | 16.31 (5.53) | ||
| Median (IQR) | 0.00 (0.00–4.34) | 16.84 (15.00–20.00) | <0.0001 | 1.195 (1.104;1.294) |
| CD31 MVD (surgical specimen) | ||||
| Mean (SD) | 7.19 (5.54) | 17.98 (5.82) | ||
| Median (IQR) | 6.00 (5.00–7.67) | 18.67 (14.00–22.34) | <0.0001 | 1.153 (1.083; 1.228) |
| pT | ||||
| T1–T2 | 17 (54.8%) | 04 (28.6%) | ||
| T3–T4 | 14 (45.2%) | 10 (71.4%) | 0.1304 | 2.450 (0.767; 7.823) |
| Pathological grade | ||||
| G1–G2 | 23 (74.2%) | 06 (42.9%) | ||
| G3 | 08 (25.8%) | 08 (57.1%) | 0.0302 | 3.250 (1.119; 9.433) |
| N status | ||||
| N0 ** | 26 (83.9%) | 08 (57.1%) | ||
| N+ | 05 (16.1%) | 06 (42.9%) | 0.0553 | 2.832 (0.977; 8.212) |
| Tumor stage | ||||
| I–II | 15 (48.4%) | 04 (28.6%) | ||
| III–IV | 16 (51.6%) | 10 (71.4%) | 0.2510 | 1.973 (0.618; 6.298) |
* p-value: Cox’s proportional hazards model; ** N0 status: cN0 3 cases; pN0 31 cases. MVD: microvessel density; SD: standard deviation; IQR: interquartile range; HR: hazard ratio; 95% CI: 95%.