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. 2020 Aug 4;12(8):2167. doi: 10.3390/cancers12082167

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Ancestor Chart within the domain “Biological Process” visualized by QuickGO. The turquoise box GO_terms on which we focused our attention. (B) STRING networks imported into Cytoscape. On the left the network formed by the 121 proteins included in GO:0030968 and GO:0036498 is reported; the eight proteins highlighted in fuchsia are those found in human multiple myeloma cell line (MM1.s)-extracellular vesicles (EVs). The network on the right shows that these eight MM1.s-EV proteins are reciprocally interconnected and five of them are directly connected to ERN1 (the inositol-requiring enzyme-1 alpha (IRE1α)). The node size indicates the number of connections of each node.