Figure 6.

Methylation levels of the CpG sites in the blood and skeletal muscle of DM1 patients compared to controls. (A) Increased methylation of upstream CpG sites can be observed in the muscle tissue of patients compared to in the blood of patients and the muscle tissue from controls. (B) There was no significant difference in the methylation levels of the downstream CpG sites between the blood and muscle tissue of the patients, and muscle tissue of the controls. There was, however, larger variance in the methylation levels of the downstream CpG sites, and the outliers were values for patients with repeat interruptions. Boxplots indicate medians and quartiles, and the dots indicate the levels of methylation for patients who are outliers.