Table 2.
Time to mortality. Crude and multivariable analysis.
| Crude Hazard Ratio (HR) | Adjusted Hazard Ratio (aHR) & | |||
|---|---|---|---|---|
| (n = 1181) | (n = 1167) | |||
| HR, (95% CI) | p-Value | aHR, (95% CI) | p-Value | |
| NSAID | 0.82 (0.48–1.40) | 0.46 | 0.89 (0.52–1.53) | 0.67 |
| Age | ||||
| Under 65 | -Ref- | -Ref- | ||
| 65 to 79 | 3.21 (2.29–4.51) | <0.001 | 3.14 (2.20–4.48) | <0.001 |
| Over 80 | 3.94 (2.82–5.50) | <0.001 | 4.00 (2.81–5.71) | <0.001 |
| Sex | ||||
| Female | -Ref- | -Ref- | ||
| Male | 0.88 (0.71–1.10) | 0.25 | 0.88 (0.70–1.11) | 0.28 |
| Smoking status | ||||
| Never | ||||
| Ex-smokers | 1.24 (1.0–1.55) | 0.06 | 1.02 (0.80–1.28) | 0.92 |
| Current smokers | 0.90 (0.56–1.42) | 0.62 | 1.11 (0.68–1.82) | 0.66 |
| Elevated CRP (>40) | 2.24 (1.65–3.05) | <0.001 | 2.75 (2.01–3.76) | <0.001 |
| Patients with diabetes | 1.09 (0.87–1.38) | 0.45 | 1.03 (0.81–1.32) | 0.80 |
| Patients with CAD | 1.47 (1.16–1.87) | 0.001 | 1.09 (0.84–1.40) | 0.53 |
| Patients with hypertension | 1.27 (1.03–1.58) | 0.03 | 0.97 (0.77–1.22) | 0.81 |
| Patients with reduced renal function (eGFR < 60) | 1.80 (1.45–2.24) | <0.001 | 1.40 (1.11–1.76) | 0.004 |
& The multivariable mixed-effects analysis was adjusted for age group, sex, smoking, C--reactive protein (CRP) level, diabetes, coronary artery disease (CAD), hypertension and renal function; eGFR, estimated glomerular filtration rate.