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. 2020 Aug 6;9(8):1847. doi: 10.3390/cells9081847

Figure 3.

Figure 3

Abnormal intestinal barrier function in TROP2 rescue mice. (a) Sizes (maximal dimensions) of mesenteric lymph nodes from relevant mouse strains were determined. Data depicted represent means ± SD of dimensions obtained from 9 mice for each group (n = 9). **** p < 0.0001 as determined via one-way ANOVA with Tukey’s multiple comparison test. (b) FITC-dextran concentrations in sera from adult WT, T2R, and hEpR mice measured 4 h after administration of 4-kDa FITC-Dextran by gavage. * p < 0.05, ** p < 0.01 as determined via one-way ANOVA with Tukey’s multiple comparison test. (c) Serial body weights of adult female WT, T2R, and hEpR mice treated with 2.5% dextran sodium sulfate (DSS) in their drinking water. * p < 0.05, ** p < 0.01, **** p < 0.0001 as determined via one-way ANOVA with Tukey’s multiple comparison test. (d) Representative H & E-stained histologic sections of colon obtained on day 5 of DSS treatment. Scale bar, 100 μm.