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. 2020 Aug 6;9(8):1847. doi: 10.3390/cells9081847

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Decreased expression and mislocalization of claudin-1 and claudin-7 in TROP2 rescue mice. (a) Normalized amounts of intestinal tissue lysate proteins were resolved using SDS-PAGE and immunoblotted with anti-hEpCAM, anti-mEpCAM, anti-mTROP2, anti-claudin-1, anti-claudin-7, and anti-β-actin. Specific proteins were detected with HRP-labeled secondary Ab and chemiluminescence. D: Duodenum, I: Ileum, P: Proximal colon, Di: Distal colon, and TAM: tamoxifen treated. (b) Claudin-1 was detected and localized via immunostaining in ileum villi and crypts of relevant mice. Claudin-1, green. Scale bars, 50 μm. (c) Claudin-7 was detected and localized via immunostaining in ileum villi and crypts of relevant mice. Claudin-7, green. Scale bars, 50 μm.