Table 1.
Preparation and process yield of the various spray-dried particles. Values are expressed as mean ± standard deviation.
| Formulation | Kanamycin (mg) | Amino Acid (mg) | Kanamycin: Amino Acid (Molar Ratio) | Final Volume (mL) | Feed Conc. (Relative to Kanamycin) | Process Yield (%), n = 2 |
|---|---|---|---|---|---|---|
| Kanamycin only (KO) | 1500 | - | - | 750 | 0.2 | 71.9 ± 3.7 |
| Kanamycin-Valine (KV) | 1500 | 301.5 | 1:1 | 750 | 0.2 | 70.7 ± 1.3 |
| Kanamycin-Methionine (KM) | 1500 | 384.0 | 1:1 | 750 | 0.2 | 74.4 ± 5.0 |
| Kanamycin-Phenylalanine (KP) | 1500 | 425.5 | 1:1 | 750 | 0.2 | 75.2 ± 2.2 |
| Kanamycin-Tryptophan (KT) | 1500 | 526.0 | 1:1 | 750 | 0.2 | 76.8 ± 1.3 |