Table 2.
Effect of amount of DFX loaded into the SNEDDS formulations on the droplet size and PDI of SNNEDS (n = 3).
| SNEDDS Formulation Code |
DFX Amount (mg/mL) | Peceol:KolliphorEL:Transcutol HP (w/w, %) | Mean Droplet Size (nm) (±SD) | Mean PDI (±SD) |
|---|---|---|---|---|
| P1-50 | 50 | 10:45:45 | 128 ± 26.20 | 0.379 ± 0.08 |
| P1-45 | 45 | 109.1 ± 1.70 | 0.498 ± 0.09 | |
| P1-40 | 40 | 73.71 ± 4.59 | 0.496 ± 0.01 | |
| P2-50 | 50 | 10:30:60 | 670 ± 147.95 | 0.885 ± 0.16 |
| P2-45 | 45 | 239.4 ± 47.87 | 0.706 ±0.27 | |
| P2-40 | 40 | 189.5 ± 2.20 | 0.496 ± 0.01 | |
| P3-50 | 50 | 10:60:30 | 95.12 ± 14.70 | 1.000 ± 0.001 |
| P3-45 | 45 | 120.5 ± 0.32 | 0.444 ± 0.01 | |
| P3-40 | 40 | 75.53 ± 63.4 | 0.546 ± 0.20 | |
| P4-50 | 50 | 10:36:54 | 165.6±2.20 | 0.352 ± 0.12 |
| P4-45 | 45 | 140.62±74.18 | 0.686 ± 0.11 | |
| P4-40 | 40 | 122.3±1.82 | 0.348 ± 0.04 | |
| P5-50 | 50 | 10:67.5:2.5 | 39.20 ± 12.34 | 0.745 ± 0.28 |
| P5-45 | 45 | 27.82 ± 0.83 | 0.803 ± 0.03 | |
| P5-40 | 40 | 14.72 ± 1.50 * | 0.214 ± 0.036 | |
| P6-50 | 50 | 10:54:36 | 81.56 ± 2.12 | 0.544 ± 0.004 |
| P6-45 | 45 | 41.28 ± 0.90 | 1.000 ± 0.001 | |
| P6-40 | 40 | 19.57 ± 0.30 | 0.578 ± 0.02 | |
| P7-50 | 50 | 10:72:18 | 33.79 ± 26.68 | 0.486 ± 0.12 |
| P7-45 | 45 | 29.02 ± 12.44 | 0.478 ± 0.19 | |
| P7-40 | 40 | 15.77 ± 3.56 * | 0.174 ± 0.03 |
* Values in bold represent the optimum droplet size values for formulations P5-40 and P7-40.